Annonaceous acetogenins as promising DNA methylation inhibitors to prevent and treat leukemogenesis – an in silico approach
U Subaramaniyam, D Ramalingam… - Journal of …, 2023 - Taylor & Francis
Leukemia is a haematological malignancy affecting blood and bone marrow, ranking 10th
among the other common cancers. DNA methylation is an epigenetic dysregulation that …
among the other common cancers. DNA methylation is an epigenetic dysregulation that …
Mechanisms of DNA methyltransferase–inhibitor interactions: Procyanidin B2 shows new promise for therapeutic intervention of cancer
DNA methyltransferases (DNMTs) is a key epigenetic enzyme for pharmacological
manipulation and is employed in cancer reprogramming. During past few years multiple …
manipulation and is employed in cancer reprogramming. During past few years multiple …
In silico identification of small natural inhibitors against DNA methyl transferase 3-like protein by integrative molecular docking and molecular dynamics approach
P Sarkar, N Niraj, V Srivastava - Chemical Biology Letters, 2023 - pubs.thesciencein.org
Tiny phytochemicals found in different types of spices may play a significant role as
anticancer drugs, particularly by focusing on a specific cancer receptor to modulate the …
anticancer drugs, particularly by focusing on a specific cancer receptor to modulate the …
Catechin-Induced changes in PODXL, DNMTs, and miRNA expression in Nalm6 cells: an integrated in silico and in vitro approach
Background This study explored the impact of predicted miRNAs on DNA
methyltransferases (DNMTs) and the PODXL gene in Nalm6 cells, revealing the significance …
methyltransferases (DNMTs) and the PODXL gene in Nalm6 cells, revealing the significance …
Halting aberrant DNA methylation via in silico Identification of potent inhibitors of DNMT3B enzyme: Atomistic insights
LM Mtetwa, EY Salifu, CA Omolo, ME Soliman… - … Biology and Chemistry, 2023 - Elsevier
To date, Cancer remains a global threat due to its impact on growing life expectancy. With
the many efforts and methods of combating the disease, complete success remains a …
the many efforts and methods of combating the disease, complete success remains a …
Identification of a potential DNA methyltransferase (DNMT) inhibitor
DNA methyltransferases (DNMTs) play an important role in the epigenetic regulation of gene
expression through the methylation of DNA. Since hypermethylation and consequent …
expression through the methylation of DNA. Since hypermethylation and consequent …
Epigenetic-based cancer therapeutics: new potential HDAC8 inhibitors
M Hassanzadeh, S Mahernia, G Caprini… - Journal of …, 2022 - Taylor & Francis
Designing dual small molecule inhibitors against enzymes associated with cancer has
turned into a new strategy in cancer chemotherapy. Targeting DNA methyltransferase …
turned into a new strategy in cancer chemotherapy. Targeting DNA methyltransferase …
Discovery of novel DNMT-1 inhibitor by fragment-based drug design as a potential breast cancer treatment
Breast cancer is the most common and lethal type of cancer among women in the world.
Epimutation is the leading cause of the tumorigenesis of breast cancer. DNA …
Epimutation is the leading cause of the tumorigenesis of breast cancer. DNA …
Effect of Withaferin-A, Withanone, and Caffeic Acid Phenethyl Ester on DNA Methyltransferases: Potential in Epigenetic Cancer Therapy
Background: DNA methyltransferases (DNMTs) have been reported to be potential drug
targets in various cancers. The major hurdle in inhibiting DNMTs is the lack of knowledge …
targets in various cancers. The major hurdle in inhibiting DNMTs is the lack of knowledge …
[PDF][PDF] Computer-aided drug design to discover DNMT inhibitors from phytochemicals
L Kumari, WRP Wijesinghe - Ceylon Journal of Science, 2024 - researchgate.net
Inhibitors of DNA methyltransferase (DNMTs) are now a major family of epigenetic targets
with therapeutic interest. However, only two cytosine analogues 5-azacytosine (azacytidine) …
with therapeutic interest. However, only two cytosine analogues 5-azacytosine (azacytidine) …