We report here the isolation of two new monoclonal antibodies (MB1. 1 and MB1. 2) against
mouse VLA-β1 integrin subunit. Characterization by flow cytometry demonstrated binding of …

We have investigated the expression and function of the VLA-4 heterodimer α4β1, a
member of the β1 integrin subfamily, on human thymic epithelial cells (TEC) derived from …

VLA molecules (beta 1 integrins) are cell-surface alpha beta heterodimers that bind to
extracellular matrix (ECM) proteins such as fibronectin, laminin, and collagen. We analyzed …

The integrin VLA-2 was previously found to bind to either collagen alone, or collagen plus
laminin, but the mechanism for this cell-specific functional difference was unknown. Here we …

The leukocyte beta 1 integrin receptor very late activation antigen-4 (VLA-4)(alpha 4 beta 1,
CD49d/CD29) binds to vascular cell adhesion molecule-1 (VCAM-1) expressed on cytokine …

Integrins can exist in a range of functional states, depending on the cell type and its state of
activation. Although the mechanism that controls activity is unknown, it has been suggested …

VLA‐4 is a cell surface heterodimer in the integrin superfamily of adhesion receptors. Anti‐
VLA‐4 antibodies inhibited cytolytic T cell activity, with inhibitory activity directed against the …

The VLA integrin subfamily includes receptors for extracellular matrix proteins as well as
receptors involved in cell-cell adhesive interactions. We have previously described the up …

Whereas all of the integrins in the VLA protein subfamily are involved in cell‐extracellular
matrix interactions, only VLA‐4 (through the α4 subunit) has been implicated in the …

Integrins are a family of cell surface heterodimers which mediate both cell‐cell and cell‐
extracellular matrix interactions and affect cellular differentiation through their signal …