Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality

HM Al-Kuraishy, AI Al-Gareeb, HA Al-Hussaniy… - International …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (Covid-19) is a worldwide infectious disease caused by
severe acute respiratory coronavirus 2 (SARS-CoV-2). In severe SARS-CoV-2 infection …

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

FP Veras, MC Pontelli, CM Silva… - Journal of Experimental …, 2020 - rupress.org
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to
cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil …

On the origin of neutrophil extracellular traps in COVID-19

M Pastorek, M Dúbrava, P Celec - Frontiers in Immunology, 2022 - frontiersin.org
Despite ongoing vaccination COVID-19 is a global healthcare problem because of the lack
of an effective targeted therapy. In severe COVID-19 manifesting as acute respiratory …

Neutrophil extracellular traps (NETs) in severe SARS-CoV-2 lung disease

M Szturmowicz, U Demkow - International journal of molecular sciences, 2021 - mdpi.com
Neutrophil extracellular traps (NETs), built from mitochondrial or nuclear DNA, proteinases,
and histones, entrap and eliminate pathogens in the course of bacterial or viral infections …

Neutrophil extracellular traps contribute to COVID-19 hyperinflammation and humoral autoimmunity

J Torres-Ruiz, A Absalón-Aguilar, M Nuñez-Aguirre… - Cells, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) is related to enhanced production of NETs, and
autoimmune/autoinflammatory phenomena. We evaluated the proportion of low-density …

Patients with COVID-19: in the dark-NETs of neutrophils

M Ackermann, HJ Anders, R Bilyy, GL Bowlin… - Cell Death & …, 2021 - nature.com
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model

FP Veras, GF Gomes, BMS Silva, DB Caetité… - Respiratory …, 2023 - Springer
Background COVID-19 is characterized by severe acute lung injury, which is associated with
neutrophil infiltration and the release of neutrophil extracellular traps (NETs). COVID-19 …

Neutrophil extracellular traps and by-products play a key role in COVID-19: pathogenesis, risk factors, and therapy

AR Thierry, B Roch - Journal of clinical medicine, 2020 - mdpi.com
Understanding of the pathogenesis of the coronavirus disease-2019 (COVID-19) remains
incomplete, particularly in respect to the multi-organ dysfunction it may cause. We were the …

Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

C Radermecker, N Detrembleur, J Guiot… - Journal of Experimental …, 2020 - rupress.org
Infection with SARS-CoV-2 is causing a deadly and pandemic disease called coronavirus
disease–19 (COVID-19). While SARS-CoV-2–triggered hyperinflammatory tissue-damaging …

[HTML][HTML] COVID-19: Role of neutrophil extracellular traps in acute lung injury

A Yaqinuddin, P Kvietys, J Kashir - Respiratory investigation, 2020 - ncbi.nlm.nih.gov
An unexplained pneumonia broke out in Wuhan, China, in December 2019. Clinical
analyses of these and subsequent similar cases attributed the pathology to a novel b …