Biomarker-guided therapy for colorectal cancer: strength in complexity

A Sveen, S Kopetz, RA Lothe - Nature Reviews Clinical Oncology, 2020 - nature.com
The number of molecularly stratified treatment options available to patients with colorectal
cancer (CRC) is increasing, with a parallel rise in the use of biomarkers to guide …

From tumour heterogeneity to advances in precision treatment of colorectal cancer

CJA Punt, M Koopman, L Vermeulen - Nature reviews Clinical oncology, 2017 - nature.com
In recent years, the high heterogeneity of colorectal cancer (CRC) has become evident.
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …

Molecular biomarkers in the personalized treatment of colorectal cancer

FA Sinicrope, K Okamoto, PM Kasi… - Clinical Gastroenterology …, 2016 - Elsevier
Colorectal cancer (CRC) is a disease in which pathogenesis is influenced by genetic and
epigenetic events that occur with tumor initiation and progression. Large variation exists in …

Prognostic and predictive molecular biomarkers for colorectal cancer: updates and challenges

E Koncina, S Haan, S Rauh, E Letellier - Cancers, 2020 - mdpi.com
Colorectal cancer (CRC) is a leading cause of death among cancer patients. This
heterogeneous disease is characterized by alterations in multiple molecular pathways …

Personalized medicine—current and emerging predictive and prognostic biomarkers in colorectal cancer

C Koulis, R Yap, R Engel, T Jardé, S Wilkins, G Solon… - Cancers, 2020 - mdpi.com
Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide and is
heterogeneous both morphologically and molecularly. In an era of personalized medicine …

The evolving biomarker landscape for treatment selection in metastatic colorectal cancer

J Taieb, A Jung, A Sartore-Bianchi, M Peeters… - Drugs, 2019 - Springer
The approval of targeted therapies for metastatic colorectal cancer (mCRC) has led to
important improvements in patient outcomes. However, it is still necessary to increase …

Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes

JF Linnekamp, X Wang, JP Medema, L Vermeulen - Cancer research, 2015 - AACR
Personalized cancer medicine is becoming increasingly important in colorectal cancer
treatment. Especially for targeted therapies, large variations between individual treatment …

Biomarkers in colorectal cancer: current research and future prospects

OO Ogunwobi, F Mahmood, A Akingboye - International journal of …, 2020 - mdpi.com
Colorectal cancer (CRC) is a leading cause of death worldwide, despite progress made in
detection and management through surgery, chemotherapy, radiotherapy, and …

A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy

V Deschoolmeester, M Baay, P Specenier… - The …, 2010 - academic.oup.com
Rapidly growing insights into the molecular biology of colorectal cancer (CRC) and recent
developments in gene sequencing and molecular diagnostics have led to high expectations …

Biomarkers in colorectal cancer

AJ Yiu, CY Yiu - Anticancer research, 2016 - ar.iiarjournals.org
Colorectal cancer is the third most common cancer worldwide, with 1.36 million people
diagnosed in 2012. The prognosis of colorectal cancer is better with an earlier diagnosis …