Many neurological disorders are accompanied by depression. Because the clinical
presentations of mood symptoms in neurological patients are similar to those seen in …

Substantial progress has been made in elucidating the pathophysiology of major depressive
disorder (MDD) using functional and structural brain imaging. In functional imaging studies …

Cognitive ability of minor depressed patients (N= 28), major depressed patients (N= 26) and
healthy elderly (N= 38) was examined cross-sectionally to determine if cognitive abilities of …

Background. Depressed patients show deficits on neuropsychological tests. However, the
basis of these impairments and their relationship with mood disturbance remains unclear …

Findings from computed tomography (CT), magnetic resonance imaging (MRI), positron
emission tomography (PET), and single photon emission computed tomography (SPECT) …

The onset and reversibility of major depression is likely to be explained by diffuse
neuromodulatory mechanisms rather than permanent abnormalities of connectivity and …

The role of specific brain regions in the pathophysiology of clinical depression is poorly
understood. However, one brain area, the prefrontal cortex, is emerging as likely being …

• Recognizing depression in brain-damaged patients poses considerable problems. The
standard dignostic criteria often are not applicable since the neurological lesion may distort …

A working model of depression implicating failure of the coordinated interactions of a
distributed network of limbic-cortical pathways is proposed. Resting state patterns of …

The last few years have witnessed a major paradigm shift in the understanding of basal
ganglia function. In line with this has been an increasing appreciation of both the centrality of …