Background Glucocorticoids play a crucial role as mediators of negative health effects
associated with chronic stress, including increased risk for psychiatric disorders as well as …

Substantial sex differences have been reported in the physiological response to stress at
multiple levels, including the release of the stress hormone, cortisol. Here, we explore the …

Chronic exposure to glucocorticoids (GCs) can lead to psychiatric complications through
epigenetic mechanisms such as DNA methylation (DNAm). We sought to determine whether …

Understanding the function of non-coding genomic sequence variants represents a
challenge for biomedicine. Many diseases are products of gene-by-environment interactions …

Glucocorticoids (GCs) are key mediators of stress response and are widely used as
pharmacological agents to treat immune diseases, such as asthma and inflammatory bowel …

Background Synthetic glucocorticoids are widely used in the treatment of several
inflammatory, autoimmune and lymphoproliferative disorders. However, considerable …

Glucocorticoids are the cornerstone of immunosuppressive and anti-inflammatory therapy in
humans, yet the mechanisms of glucocorticoid immunoregulation and toxicity remain …

Post-traumatic stress disorder (PTSD) results from severe trauma exposure, but the extent to
which genetic and epigenetic risk factors impact individual clinical outcomes is unknown …

Objective Cushing's syndrome represents a state of excessive glucocorticoids related to
glucocorticoid treatments or to endogenous hypercortisolism. Cushing's syndrome is …

Osteoporosis is the most common bone metabolic disease, characterized by bone mass loss
and bone microstructure changes due to unbalanced bone conversion, which increases …