Crohn's disease and ulcerative colitis are prototypical complex diseases characterized by
chronic and heterogeneous manifestations, induced by interacting environmental, genomic …

Inflammatory bowel disease (IBD) is presently one of the most investigated human
disorders. Expansion of knowledge of its pathophysiology has helped in developing novel …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

Microbe–host communication is essential to maintain vital functions of a healthy host, and its
disruption has been associated with several diseases, including Crohn's disease and …

Ulcerative colitis and Crohn's disease are the 2 major phenotypes of inflammatory bowel
disease (IBD), which are influenced by a complex interplay of immunological and genetic …

The pathogenesis of all immune-mediated inflammatory diseases has been carefully studied
over the past several decades, but it is only recently that we have come to appreciate …

Abstract The IBDs, Crohn's disease and ulcerative colitis, are chronic inflammatory
conditions of the gastrointestinal tract resulting from an aberrant immune response to enteric …

IBD is a spectrum of chronic disorders that constitute an important health problem
worldwide. The hunt for genetic determinants of disease onset and course has culminated in …

The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …

Abstract Background Inflammatory Bowel Disease (IBD) is a multifactorial chronic disease.
Understanding only one aspect of IBD pathogenesis does not reflect the complex nature of …