Infections caused by resistant bacteria are nowadays too common, and some pathogens
have even become resistant to multiple types of antibiotics, in which case few or even no …

The increasing incidence and prevalence of multi-drug resistance (MDR) among
contemporary Gram-negative bacteria represents a significant threat to human health. Since …

Antimicrobial resistance constitutes one of the major threats regarding pathogenic
microorganisms. Gramnegative pathogens, such as Enterobacteriaceae (specially those …

Although the need for new antibacterial therapies and strategies is greater than it has been
in a quarter of a century and despite considerable effort, little progress has been observed in …

Recent regulatory approvals for the β-lactam inhibitor combinations of ceftazidime–
avibactam and meropenem–vaborbactam have provided two novel therapeutic options for …

β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial
agents for treating both Gram-negative and Gram-positive bacterial infections. The β-lactam …

Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously
threatens our capability to treat bacterial diseases, including potentially deadly hospital …

Importance of the field: β-Lactam antibiotics are among the most frequently prescribed
antibiotics used to treat bacterial infections. However, their utility is being threatened by the …

Abstract β-Lactam antibiotics are one of the most relevant drug classes of antibacterial
agents worldwide. The discovery and the market of first β-lactam antibiotic (Penicillin G) is a …

Bacterial resistance to antibiotics is growing up day by day in both community and hospital
setting, with a significant impact on the mortality and morbidity rates and the financial burden …