Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

Previous studies have demonstrated that mitochondrial respiration is essential for
tumorigenesis. Hui et al.(2017) and Faubert et al.(2017) demonstrate that lactate …

Mg 2+ is the most abundant divalent cation in metazoans and an essential cofactor for ATP,
nucleic acids, and countless metabolic enzymes. To understand how the spatio-temporal …

It is well established that lactate secreted by fermenting cells can be oxidized or used as a
gluconeogenic substrate by other cells and tissues. It is generally assumed, however, that …

Lactate has long been regarded as an end product of anaerobic energy production and its
fate in cerebral metabolism has not been precisely delineated. In this report, we …

Research over the past seventy years has established that mitochondrial-l-lactate
dehydrogenase (mL-LDH) is vital for mitochondrial bioenergetics. However, in recent report …

To evaluate the potential role of mitochondrial lactate dehydrogenase (LDH) in tissue lactate
clearance and oxidation in vivo, isolated rat liver, cardiac, and skeletal muscle mitochondria …

There appears to be general agreement among many authors on key aspects of the lactate
shuttle concept, ie that the production, exchange and utilization of lactate are major means …

Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these
compensatory pathways may produce synthetic lethality. We previously demonstrated that …

Glucose is a 6-carbon structure with the chemical formula C6H12O6. It is a ubiquitous
source of energy for every organism in the world and is essential to fuel both aerobic and …