Protein aggregation and oxidative stress are two pathological hallmarks of a number of
protein misfolding diseases, including Huntington's disease (HD). Whether protein …

Aggregation of protein molecules is a pathological hallmark of many neurodegenerative
diseases. Abnormal modifications have often been observed in the aggregated proteins …

Neurodegenerative diseases are characterized by intra-and/or extracellular protein
aggregation and oxidative stress. Intense attention has been paid to whether protein …

Increasing evidence in recent years indicates that protein misfolding and aggregation,
leading to ER stress, are central factors of pathogenicity in neurodegenerative diseases …

The classical reports on neurodegeneration concentrate on studying disruption of signalling
cascades. Although it is now well recognized that misfolding and aggregation of specific …

Formation of cytoplasmic and nuclear aggregates is a hallmark of Huntington's disease
(HD). Inhibition of aggregation of mutant huntingtin has been suggested to be a feasible …

Misfolded proteins accumulate in many neurodegenerative diseases, including huntingtin in
Huntington's disease and α-synuclein in Parkinson's disease. The disease-causing proteins …

A hallmark of Huntington's disease is the presence of a large polyglutamine expansion in
the first exon of the Huntingtin protein and the propensity of protein aggregation by the …

Protein misfolding and aggregation are associated with many neurodegenerative diseases,
including Huntington's disease. The cellular machinery for maintaining proteostasis includes …

Onset of protein aggregation reflects failure of the cellular folding machinery to keep
aggregation-prone protein from misfolding and accumulating into a non-degradable state …