Quantitative analysis of the proliferative-to-invasive transition of hypoxic glioma cells
H Gomez - Integrative Biology, 2017 - academic.oup.com
Hypoxia is a hallmark of gliomas that is often associated with poor prognosis and resistance
to therapies. Insufficient oxygen supply reduces the proliferation rate of tumor cells, which …
to therapies. Insufficient oxygen supply reduces the proliferation rate of tumor cells, which …
Hypoxia in gliomas: opening therapeutical opportunities using a mathematical-based approach
This chapter explores the use of mathematical models as promising and powerful tools to
understand the complexity of tumors and their, frequently, hypoxic environment. We focus on …
understand the complexity of tumors and their, frequently, hypoxic environment. We focus on …
Hypoxic and reoxygenated microenvironment: stemness and differentiation state in glioblastoma
MM Gaelzer, MS Santos, BP Coelho… - Molecular …, 2017 - Springer
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in
adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression …
adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression …
Hypoxia, angiogenesis and mechanisms for invasion of malignant gliomas
P Province, CE Griguer, X Han, NB Louis… - Evolution of the …, 2013 - books.google.com
Malignant gliomas are not only the most frequent primary brain tumor in the adult pop‐-
ulation, but also the most aggressive. Despite recent therapeutic advances, they remain …
ulation, but also the most aggressive. Despite recent therapeutic advances, they remain …
Quantitative metrics of net proliferation and invasion link biological aggressiveness assessed by MRI with hypoxia assessed by FMISO-PET in newly diagnosed …
Glioblastoma multiforme (GBM) are aggressive and uniformly fatal primary brain tumors
characterized by their diffuse invasion of the normal-appearing parenchyma peripheral to …
characterized by their diffuse invasion of the normal-appearing parenchyma peripheral to …
Hypoxia in the initiation and progression of neuroblastoma tumours
C Huertas-Castaño, MA Gómez-Muñoz… - International journal of …, 2019 - mdpi.com
Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all
paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled …
paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled …
Hypoxic cell waves around necrotic cores in glioblastoma: a biomathematical model and its therapeutic implications
A Martínez-González, GF Calvo… - Bulletin of mathematical …, 2012 - Springer
Glioblastoma is a rapidly evolving high-grade astrocytoma that is distinguished
pathologically from lower grade gliomas by the presence of necrosis and microvascular …
pathologically from lower grade gliomas by the presence of necrosis and microvascular …
A mathematical model for glioma growth and invasion links biological aggressiveness assessed by MRI with hypoxia assessed by FMISO-PET
517 Objectives: Malignant gliomas are aggressive primary brain tumors characterized by
their diffuse invasion of the normal appearing parenchyma peripheral to the clinical imaging …
their diffuse invasion of the normal appearing parenchyma peripheral to the clinical imaging …
Speed switch in glioblastoma growth rate due to enhanced hypoxia-induced migration
We analyze the wave speed of the Proliferation Invasion Hypoxia Necrosis Angiogenesis
(PIHNA) model that was previously created and applied to simulate the growth and spread …
(PIHNA) model that was previously created and applied to simulate the growth and spread …
Evidence for hypoxia increasing the tempo of evolution in glioblastoma
Background Tumour hypoxia is associated with metastatic disease, and while there have
been many mechanisms proposed for why tumour hypoxia is associated with metastatic …
been many mechanisms proposed for why tumour hypoxia is associated with metastatic …