Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond

N Grarup, CH Sandholt, T Hansen, O Pedersen - Diabetologia, 2014 - Springer
During the past 7 years, genome-wide association studies have shed light on the
contribution of common genomic variants to the genetic architecture of type 2 diabetes …

Progress in the genetics of common obesity and type 2 diabetes

KS Vimaleswaran, RJF Loos - Expert reviews in molecular medicine, 2010 - cambridge.org
The prevalence of obesity and diabetes, which are heritable traits that arise from the
interactions of multiple genes and lifestyle factors, continues to rise worldwide, causing …

Type 2 diabetes and obesity: genomics and the clinic

ME Travers, MI McCarthy - Human genetics, 2011 - Springer
Abstract Type 2 diabetes (T2D) and obesity represent major challenges for global public
health. They are at the forefront of international efforts to identify the genetic variation …

Human genetics of obesity and type 2 diabetes mellitus: past, present, and future

E Ingelsson, MI McCarthy - Circulation: Genomic and Precision …, 2018 - Am Heart Assoc
Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk
factors for cardiovascular disease, and are destined to increase in importance given the …

Insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of obesity-related traits

T Karaderi, AW Drong, CM Lindgren - Current diabetes reports, 2015 - Springer
Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are
caused by an interchange between environmental and genetic factors. Recently, a number …

Mechanisms of disease: genetic insights into the etiology of type 2 diabetes and obesity

CM Lindgren, MI McCarthy - Nature clinical practice Endocrinology & …, 2008 - nature.com
Until recently, progress in identification of the genetic variants influencing predisposition to
common forms of diabetes and obesity has been slow, a sharp contrast to the large number …

Genetics and epigenetics in the obesity phenotyping scenario

K Trang, SFA Grant - Reviews in endocrine and metabolic disorders, 2023 - Springer
Obesity is a common complex trait that elevates the risk for various diseases, including type
2 diabetes and cardiovascular disease. A combination of environmental and genetic factors …

The genetic and epigenetic basis of type 2 diabetes and obesity

AW Drong, CM Lindgren… - Clinical Pharmacology & …, 2012 - Wiley Online Library
Type 2 diabetes (T2D) and obesity are complex disorders that constitute major public health
problems. The evidence for familial aggregation of both T2D and obesity is substantial. To …

Genetic susceptibility to type 2 diabetes and obesity: follow‐up of findings from genome‐wide association studies

KJ Basile, ME Johnson, Q Xia… - International journal of …, 2014 - Wiley Online Library
Elucidating the underlying genetic variations influencing various complex diseases is one of
the major challenges currently facing clinical genetic research. Although these variations are …

Genome–wide association studies provide new insights into type 2 diabetes aetiology

TM Frayling - Nature Reviews Genetics, 2007 - nature.com
Human geneticists are currently in the middle of a race. Thanks to a new technology in the
form of'genome-wide chips', investigators can potentially find many novel disease genes in …