Cannabinoids act at two classical cannabinoid receptors (CB1 and CB2), a 7TM orphan
receptor and the transmitter‐gated channel transient receptor potential vanilloid type‐1 …

Cannabinoids act via cell surface G protein-coupled receptors (CB1 and CB2) and the ion
channel receptor TRPV1. Evidence has now emerged suggesting that an additional target is …

Some cannabinoids activate the different isoforms of PPARs (α, β and γ), as shown through
the use of reporter gene assays, binding studies, selective antagonists and knockout …

Cannabinoids have been used medicinally and recreationally for thousands of years and
their effects were proposed to occur mainly via activation of the G‐protein‐coupled receptor …

Cannabinoids have been shown to possess anti-inflammatory and neuroprotective
properties, which were proposed to occur mainly via activation of the G-protein-coupled …

Background and purpose: Although CB 1 receptor activation evokes neuroprotection in
response to cannabinoids, some cannabinoids have been reported to be peroxisome …

Peroxisome proliferator-activated receptors (PPARs) have long been known as mediators of
several physiological functions, among which the best characterized are lipid metabolism …

An increasing number of cannabinoid actions are being reported that do not appear to be
mediated by either CB1 or CB2, the known cannabinoid receptors. One such example is the …

Mammalian tissues express at least two cannabinoid receptor types, CB 1 and CB 2, both G
protein coupled. CB 1 receptors are found predominantly at nerve terminals where they …

We have shown that the major active agent of Cannabis sativa, Δ9-tetrahydrocannabinol,
activates peroxisome proliferator-activated receptor gamma [PPARγ, O'Sullivan, SE, Tarling …