Abstract Phospholipase A 2 (PLA 2) enzymes are the upstream regulators of the eicosanoid
pathway liberating free arachidonic acid from the sn-2 position of membrane phospholipids …

Considerable progress has been made in characterizing the individual participant enzymes
and their relative contributions in the generation of eicosanoids, lipid mediators derived from …

Phospholipase A2 (PLA2 catalyzes the hydrolysis of the sn-2 position of membrans
glyerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …

Abstract Phospholipase A 2 (PLA 2) enzymes catalyze the hydrolysis of ester bonds at sn-2
positions of glycerophospholipids (PL), producing free fatty acids and lysophospholipids. In …

Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …

Publisher Summary This chapter introduces the recent advances in the diversity, enzymatic
properties, and functions of the sPLA 2 family emphasizing particularly on the roles of each …

Phospholipase A2 (PLA2) constitutes a growing superfamily of lipolytic enzymes, and to
date, at least 19 distinct enzymes have been found in mammals. This class of enzymes has …

The hydrolysis of membrane phospholipid by phospholipase A2 (PLA2) is a key step in the
production of inflammatory eicosanoids. Recent cell studies have shown that secretory …

Phospholipase A2 (PLA2) enzymes cleave esterified fatty acids from membrane
glycerophospholipids. The 20‐carbon polyunsaturated fatty acid, arachidonic acid, is used …

Membrane phospholipid is an important reservoir for the generation of bioactive mediators.
Cellular phospholipases hydrolyze membrane phospholipid in a structurally specific manner …