The transition to air breathing after birth requires both anatomic and biochemical maturation
of the lung. Lung morphogenesis is mediated by complex paracrine interactions between …

The fluid-filled lung exists in relative hypoxia in utero (∼ 25 mm Hg), but at birth fills with
ambient air where the partial pressure of oxygen is∼ 150 mm Hg. The impact of this change …

Lung Kruppel-like factor (LKLF) is a member of the Kruppel-like factor family of transcription
factors and is highly expressed in lung with limited distribution in other tissues. Mice lacking …

Kruppel-like factor 2 (KLF2) is expressed in several cell types, and knockout animals have
shown that KLF2 gene regulation is involved in multiple biological processes. These include …

Fetal lung development is a complex biological process that involves temporal and spatial
regulations of many genes. To understand the molecular mechanisms of this process, we …

The zinc-finger transcription factor Krüppel-like factor-2 plays an important role in pulmonary
development, inhibition of adipocyte differentiation, and maintaining quiescence in single …

Lung Kruppel-like factor (LKLF) is a zinc finger transcription factor critical for embryonic
development. We have previously identified and isolated the mouse LKLF gene and …

Krüppel-like factor 4 (Klf4) is a transcription factor involved in differentiation and proliferation
in multiple tissues. We demonstrated previously that tamoxifen-induced deletion of the Klf4 …

Development of the pulmonary system is essential for terrestrial life. The molecular
pathways that regulate this complex process are beginning to be defined, and such …

Rationale: Acute respiratory distress syndrome (ARDS) is caused by widespread endothelial
barrier disruption and uncontrolled cytokine storm. Genome-wide association studies …