Microbe-metabolite-host axis, two-way action in the pathogenesis and treatment of human autoimmunity

X Meng, HY Zhou, HH Shen, E Lufumpa, XM Li… - Autoimmunity …, 2019 - Elsevier
The role of microorganism in human diseases cannot be ignored. These microorganisms
have evolved together with humans and worked together with body's mechanism to maintain …

The gut microbiota: emerging evidence in autoimmune diseases

X Zhang, L Zhao, H Li - Trends in molecular medicine, 2020 - cell.com
The pathogenesis of autoimmune diseases (AIDs) is not only attributed to genetic
susceptibilities but also environmental factors, among which, disturbed gut microbiota has …

The role of exposomes in the pathophysiology of autoimmune diseases II: Pathogens

A Vojdani, E Vojdani, AZ Rosenberg, Y Shoenfeld - Pathophysiology, 2022 - mdpi.com
In our continuing examination of the role of exposomes in autoimmune disease, we use this
review to focus on pathogens. Infections are major contributors to the pathophysiology of …

Host–microbiota interactions in immune-mediated diseases

WE Ruff, TM Greiling, MA Kriegel - Nature Reviews Microbiology, 2020 - nature.com
Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this …

Two faces of microbiota in inflammatory and autoimmune diseases: triggers and drugs

M Kverka, H Tlaskalova‐Hogenova - Apmis, 2013 - Wiley Online Library
The prevalence of chronic autoimmune and inflammatory diseases, such as inflammatory
bowel disease, allergies, or rheumatic diseases, is steadily increasing in developed …

The mammalian metaorganism: a holistic view on how microbes of all kingdoms and niches shape local and systemic immunity

S Runge, SP Rosshart - Frontiers in Immunology, 2021 - frontiersin.org
The field of microbiome research has developed rapidly over the past decades and has
become a topic of major interest to basic, preclinical, and clinical research, the …

Autoimmune host–microbiota interactions at barrier sites and beyond

WE Ruff, MA Kriegel - Trends in molecular medicine, 2015 - cell.com
The microbiota is considered to be an important factor influencing the pathogenesis of
autoimmunity at both barrier sites and internal organs. Impinging on innate and adaptive …

Evolving concepts of host–pathobiont interactions in autoimmunity

MS Pereira, MA Kriegel - Current Opinion in Immunology, 2023 - Elsevier
Autoimmune diseases are complex, multifactorial diseases with a polygenic trait and diverse
environmental factors that contribute to triggering and exacerbating each disorder. The …

Pathogens, commensal symbionts, and pathobionts: discovery and functional effects on the host

M Hornef - ILAR journal, 2015 - academic.oup.com
During the last decade, we have witnessed a stunning increase in information on the
composition of the microbiota; its influence on a variety of host functions; and associations …

Host–microbiota interplay in mediating immune disorders

KM Felix, S Tahsin, HJJ Wu - Annals of the New York Academy …, 2018 - Wiley Online Library
To maintain health, the immune system must maintain a delicate balance between
eliminating invading pathogens and avoiding immune disorders such as autoimmunity and …