Cancer is a disease in which the controls that usually ensure the coordinated behaviour of
individual cells break down. This rarely happens all at once. Instead, the clone of cells that …

Many cancers are aneuploid. However, the precise role that chromosomal instability plays in
the development of cancer and in the response of tumours to treatment is still hotly debated …

Numerical chromosomal instability is a ubiquitous feature of human neoplasms. Due to
experimental limitations, fundamental characteristics of karyotypic changes in cancer are …

Cancer cells frequently undergo chromosome missegregation events during mitosis,
whereby the copies of a given chromosome are not distributed evenly among the two …

The role of aneuploidy (the cellular state of having an abnormal number of chromosomes) in
cancer is not well understood. A recent theory suggests that aneuploidy may be an initial …

A stochastic model of chromosomal instability has been previously developed which has
included one adjustable parameter—the probability of a segregation error. Using computer …

As cancer cell populations evolve, they accumulate a number of somatic mutations, resulting
in heterogeneous subclones in the final tumor. Understanding the mechanisms that produce …

Tumors consist of a hierarchical population of cells that differ in their phenotype and
genotype. This hierarchical organization of cells means that a few clones (ie, cells and …

The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy
is associated with increases in genomic instability. Mitotic chromosomal instability—the …

Modeling mis-segregations is hard because of the sheer number of possible karyotypes.
More than 70 quintillions (considering 8 states/chr)! We derived a deterministic framework …