Background: Drug effects can be investigated through natural variation in the genes for their
protein targets. The present study aimed to use this approach to explore the potential side …

Conclusions Common variants may influence response to diuretics, beta-blockers,
angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers, but studies of …

BACKGROUND: Selection of antihypertensive therapy is often empiric, and use of genetic
information to guide drug therapy selection holds future promise. TRIAL DESIGN: The …

Hypertension is a common disorder associated with increased cardiovascular morbidity and
mortality. Unfortunately, in the US only about one-third of those who are aware of their …

Pharmacogenetic investigation seeks to identify genetic factors that contribute to interpatient
and interdrug variation in responses to antihypertensive drug therapy. Classical studies …

Hypertension is a multifactorial disease that affects approximately one billion subjects
worldwide and is a major risk factor associated with cardiovascular events, including …

Hypertension is one of the strongest modifiable cardiovascular risk factors, affecting an
increasing number of people worldwide. Apart from poor medication adherence, the low …

Background Identification of genetic markers of antihypertensive drug responses could
assist in individualization of hypertension treatment. Methods and Results We conducted a …

Cardiovascular and renal diseases are associated with many risk factors, of which
hypertension is one of the most prevalent. Worldwide, blood pressure control is only …

The past decade has seen tremendous advances in our understanding of the genetic factors
influencing response to a variety of drugs, including those targeted at treatment of …