Insulin resistance and other risk factors for atherosclerosis, such as hypertension and
hypercholesterolemia, promote endothelial dysfunction and lead to development of …

Abstract The International Diabetes Federation estimates that 316 million people are
currently affected by impaired glucose tolerance (IGT). Most importantly, recent forecasts …

Cardiovascular disease affects approximately 60% of the adult population over the age of 65
and represents the number one cause of death in the United States. Coronary …

Endothelial dysfunction is an imbalance in the production of vasodilator factors and when
this balance is disrupted, it predisposes the vasculature towards pro-thrombotic and pro …

Insulin resistance is the main pathologic mechanism that links the constellation of clinical,
metabolic and anthropometric traits with increased risk for cardiovascular disease and type II …

Patients with diabetes mellitus (DM) have a high prevalence of coronary artery disease
(CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Endothelial …

Endothelium plays a crucial role in modulating vascular function and structure, mainly by
production of nitric oxide which protects the vasculature against the development of …

Hypertension, a prevalent risk factor for cardiovascular disease, frequently occurs in
conjunction with metabolic disturbances and in particular with dyslipidaemia; such …

Cardiovascular disease is a leading cause of death and disability in patients with diabetes
or metabolic syndrome (MS). The available data suggest that many patients with diabetes or …

Endothelial dysfunction plays a key role in the initiation of cellular events evolving into the
development of vascular complications in diabetes and hypertension. Diminished …