[HTML][HTML] Crystal structure of two CD46 domains reveals an extended measles virus‐binding surface

JM Casasnovas, M Larvie, T Stehle - The EMBO journal, 1999 - embopress.org
Measles virus is a paramyxovirus which, like other members of the family such as respiratory
syncytial virus, is a major cause of morbidity and mortality worldwide. The cell surface …

Octamerization enables soluble CD46 receptor to neutralize measles virus in vitro and in vivo

D Christiansen, P Devaux, B Réveil, A Evlashev… - Journal of …, 2000 - Am Soc Microbiol
ABSTRACT A chimeric fusion protein encompassing the CD46 ectodomain linked to the C-
terminal part of the C4b binding protein (C4bp) α chain (sCD46-C4bpα) was produced in …

Measles virus recognizes its receptor, CD46, via two distinct binding domains within SCR1-2

M Manchester, JE Gairin, JB Patterson, J Alvarez… - Virology, 1997 - Elsevier
Measles virus (MV) enters cells by attachment of the viral hemagglutinin to the major cell
surface receptor CD46 (membrane cofactor protein). CD46 is a transmembrane glycoprotein …

Measles virus receptor properties are shared by several CD46 isoforms differing in extracellular regions and cytoplasmic tails

D Gerlier, B Loveland… - Journal of general …, 1994 - microbiologyresearch.org
Human CD46, a member of the family of regulators of complement activation, has been
shown recently to act as a measles virus (MV) receptor, interacting with the virus envelope …

Structural and functional studies of the measles virus hemagglutinin: identification of a novel site required for CD46 interaction

JB Patterson, F Scheiflinger, M Manchester, T Yilma… - Virology, 1999 - Elsevier
The entry of measles virus (MV) into human cells is mediated by the initial attachment of the
viral hemagglutinin (HA) to the complement regulatory protein CD46. Two subdomains, one …

Selective expression of a subset of measles virus receptor-competent CD46 isoforms in human brain

CJ Buchholz, D Gerlier, A Hu, T Cathomen… - Virology, 1996 - Elsevier
The human cell surface protein CD46 is the main measles virus (MV) receptor. We analyzed
the CD46 isoforms expressed in the brain of three patients who died with persistent MV …

Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46).

M Manchester, A Valsamakis… - Proceedings of the …, 1995 - National Acad Sciences
The human complement regulatory protein membrane cofactor protein (CD46) is the cellular
receptor for measles virus (MV), whereas decay accelerating factor (DAF; CD55), a …

Mapping of the primary binding site of measles virus to its receptor CD46

CJ Buchholz, D Koller, P Devaux… - Journal of Biological …, 1997 - ASBMB
The measles virus (MV) hemagglutinin binds to the complement control protein (CCP) CD46
primarily through the two external modules, CCP-I and-II. To define the residues involved in …

Mapping amino acids of the measles virus hemagglutinin responsible for receptor (CD46) downregulation

R Bartz, U Brinckmann, LM Dunster, B Rima… - Virology, 1996 - Elsevier
We compared the amino acid sequences of groups of receptor (CD46) downregulating and
nondownregulating measles virus (MV) hemagglutinins (Hs) and identified seven group …

Identification of a cytoplasmic Tyr-XX-Leu motif essential for down regulation of the human cell receptor CD46 in persistent measles virus infection

S Yant, A Hirano, TC Wong - Journal of virology, 1997 - Am Soc Microbiol
To investigate the sequence requirements for measles virus (MV)-induced receptor down
regulation, we transfected the human CD46 gene into simian cells persistently infected by …