Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19

CI van der Made, MG Netea, FL van der Veerdonk… - Genome medicine, 2022 - Springer
Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights
have been gained into virus biology and the host factors that modulate the human immune …

Host genetic factors determining COVID-19 susceptibility and severity

TP Velavan, SR Pallerla, J Rüter, Y Augustin… - …, 2021 - thelancet.com
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2
(SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections …

Immunogenetic association underlying severe COVID-19

K McCoy, A Peterson, Y Tian, Y Sang - Vaccines, 2020 - mdpi.com
SARS-CoV2 has caused the current pandemic of new coronavirus disease 2019 (COVID-
19) worldwide. Clinical outcomes of COVID-19 illness range broadly from asymptotic and …

Deciphering the role of host genetics in susceptibility to severe COVID-19

ME Carter-Timofte, SE Jørgensen, MR Freytag… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following
infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst …

Host genomics of SARS-CoV-2 infection

C Redin, CW Thorball, J Fellay - European Journal of Human Genetics, 2022 - nature.com
SARS-CoV-2 infected a large fraction of humans in the past 2 years. The clinical
presentation of acute infection varies greatly between individuals, ranging from …

The human genetic epidemiology of COVID-19

MEK Niemi, MJ Daly, A Ganna - Nature Reviews Genetics, 2022 - nature.com
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …

The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic review

A Elhabyan, S Elyaacoub, E Sanad, A Abukhadra… - Virus research, 2020 - Elsevier
Background Susceptibility to severe viral infections was reported to be associated with
genetic variants in immune response genes using case reports and GWAS studies. SARS …

Human genomics of COVID-19 pneumonia: Contributions of rare and common variants

A Cobat, Q Zhang… - Annual review of …, 2023 - annualreviews.org
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign
in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of …

Host/genetic factors associated with COVID-19 call for precision medicine

AR Thierry - Precision Clinical Medicine, 2020 - academic.oup.com
If the current rate of infection are to be better managed, and future waves of infection kept at
bay, it is absolutely necessary that the conditions and mechanisms of exposure to Severe …

Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity

C Anastassopoulou, Z Gkizarioti, GP Patrinos… - Human genomics, 2020 - Springer
Background The emergence of the novel coronavirus in Wuhan, Hubei Province, China, in
December 2019 marked the synchronization of the world to a peculiar clock that is counting …