Expression of periaxin (PRX) specifically in the human cerebrovascular system: PDZ domain-mediated strengthening of endothelial barrier function

MM Wang, X Zhang, SJ Lee, S Maripudi, RF Keep… - Scientific reports, 2018 - nature.com
Regulation of cerebral endothelial cell function plays an essential role in changes in blood-
brain barrier permeability. Proteins that are important for establishment of endothelial tight …

Signaling Role of Pericytes in Vascular Health and Tissue Homeostasis

A Fazio, I Neri, FD Koufi, MV Marvi, A Galvani… - International Journal of …, 2024 - mdpi.com
Pericytes are multipotent cells embedded within the vascular system, primarily surrounding
capillaries and microvessels where they closely interact with endothelial cells. These cells …

Understanding the heterogeneity of human pericyte subsets in blood–brain barrier homeostasis and neurological diseases

DG Bohannon, D Long, WK Kim - Cells, 2021 - mdpi.com
Pericytes are increasingly recognized as being important in the control of blood–brain
barrier permeability and vascular flow. Research on this important cell type has been …

Multifaceted roles of pericytes in central nervous system homeostasis and disease

Z Zheng, M Chopp, J Chen - Journal of Cerebral Blood Flow …, 2020 - journals.sagepub.com
Pericytes, the mural cells surrounding microcirculation, are gaining increasing attention for
their roles in health and disease of the central nervous system (CNS). As an essential part of …

Pericytes and neurovascular function in the healthy and diseased brain

LS Brown, CG Foster, JM Courtney, NE King… - Frontiers in cellular …, 2019 - frontiersin.org
Pericytes are multi-functional cells embedded within the walls of capillaries throughout the
body, including the brain. Pericytes were first identified in the 1870s, but little attention was …

Single-cell analysis of blood-brain barrier response to pericyte loss

MA Mäe, L He, S Nordling… - Circulation …, 2021 - Am Heart Assoc
Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood
vessels during development and tissue repair. Loss of pericytes has been described in …

Tissue specific origin, development, and pathological perspectives of pericytes

T Yamazaki, Y Mukouyama - Frontiers in cardiovascular medicine, 2018 - frontiersin.org
Pericytes are mural cells surrounding blood vessels, adjacent to endothelial cells. Pericytes
play critical roles in maturation and maintenance of vascular branching morphogenesis. In …

Pericyte structural remodeling in cerebrovascular health and homeostasis

AA Berthiaume, DA Hartmann, MW Majesky… - Frontiers in aging …, 2018 - frontiersin.org
The biology of brain microvascular pericytes is an active area of research and discovery, as
their interaction with the endothelium is critical for multiple aspects of cerebrovascular …

[HTML][HTML] Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging

RD Bell, EA Winkler, AP Sagare, I Singh, B LaRue… - Neuron, 2010 - cell.com
Pericytes play a key role in the development of cerebral microcirculation. The exact role of
pericytes in the neurovascular unit in the adult brain and during brain aging remains …

Central nervous system pericytes in health and disease

EA Winkler, RD Bell, BV Zlokovic - Nature neuroscience, 2011 - nature.com
Pericytes are uniquely positioned within the neurovascular unit to serve as vital integrators,
coordinators and effectors of many neurovascular functions, including angiogenesis, blood …