Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models
Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide,
is highly heritable. While COPD is clinically defined by applying thresholds to summary …
is highly heritable. While COPD is clinically defined by applying thresholds to summary …
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association …
and is the third leading cause of death globally. Through genome-wide association …
Disease progression modeling in chronic obstructive pulmonary disease
Rationale: The decades-long progression of chronic obstructive pulmonary disease (COPD)
renders identifying different trajectories of disease progression challenging. Objectives: To …
renders identifying different trajectories of disease progression challenging. Objectives: To …
Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …
but the individual variants that have been identified have small effects. We hypothesised that …
Refining susceptibility loci of chronic obstructive pulmonary disease with lung eqtls
M Lamontagne, C Couture, DS Postma, W Timens… - PloS one, 2013 - journals.plos.org
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of mortality
worldwide. Recent genome-wide association studies (GWAS) have identified robust …
worldwide. Recent genome-wide association studies (GWAS) have identified robust …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
Machine learning and prediction of all-cause mortality in COPD
Background COPD is a leading cause of mortality. Research Question We hypothesized that
applying machine learning to clinical and quantitative CT imaging features would improve …
applying machine learning to clinical and quantitative CT imaging features would improve …
Integration of multi-omics datasets enables molecular classification of COPD
CX Li, CE Wheelock, CM Sköld… - European Respiratory …, 2018 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is an umbrella diagnosis caused by a
multitude of underlying mechanisms, and molecular sub-phenotyping is needed to develop …
multitude of underlying mechanisms, and molecular sub-phenotyping is needed to develop …