Corynebacterium glutamicum is an important organism for the industrial production of amino
acids. Metabolic pathways in this organism are usually engineered by conventional methods …

Genome engineering of Corynebacterium glutamicum, an important industrial
microorganism for amino acids production, currently relies on random mutagenesis and …

Corynebacterium glutamicum is an important workhorse for industrial production of
diversiform bioproducts. Multiplex control of metabolic pathway genes is crucial for …

Background Corynebacterium glutamicum is an important industrial workhorse and
advanced genetic engineering tools are urgently demanded. Recently, the clustered …

Highlights•Corynebacterium glutamicum has been used for many applications beyond
amino acids.•Economical, high-quality genome assemblies foster development of non-type …

Background Extensive modification of genome is an efficient manner to regulate the
metabolic network for producing target metabolites or non-native products using …

Abstract Development of hyperproducing strains is important for biomanufacturing of
biochemicals and biofuels but requires extensive efforts to engineer cellular metabolism and …

Abstract l-Amino acids find various applications in biotechnology. l-Glutamic acid and its
salts are used as flavor enhancers. Other l-amino acids are used as food or feed additives …

Background Corynebacterium glutamicum (C. glutamicum) has traditionally been used as a
microbial cell factory for the industrial production of many amino acids and other industrially …

Abstract CRISPR/Cas9 or Cpf1-introduced double strand break dramatically decreases
bacterial cell survival rate, which hampers multiplex genome editing in bacteria. In addition …