Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …

Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational
models using DNA methylation data can create “epigenetic clocks” which are proposed to …

Human DNA-methylation data have been used to develop highly accurate biomarkers of
aging (" epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for …

Background Epigenetic clocks based on DNA methylation yield high correlations with
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …

Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …

Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …

Epigenetic clocks are mathematically derived age estimators that are based on
combinations of methylation values that change with age at specific CpGs in the genome …

Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …