Spike protein of SARS-CoV-2 variants: a brief review and practical implications

KL Candido, CR Eich, LO de Fariña… - Brazilian Journal of …, 2022 - Springer
The scientific community has been alarmed by the possible immunological evasion, higher
infectivity, and severity of disease caused by the newest variants of SARS-CoV-2. The spike …

Mutations in SARS-CoV-2 leading to antigenic variations in spike protein: a challenge in vaccine development

PK Singh, U Kulsum, SB Rufai… - Journal of laboratory …, 2020 - thieme-connect.com
Objectives The spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
virus has been unprecedentedly fast, spreading to more than 180 countries within 3 months …

[HTML][HTML] The spike glycoprotein of SARS-CoV-2: A review of how mutations of spike glycoproteins have driven the emergence of variants with high transmissibility and …

PFN Souza, FP Mesquita, JL Amaral… - International journal of …, 2022 - Elsevier
Abstract Late in 2019, SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2)
emerged, causing an unknown type of pneumonia today called coronaviruses disease 2019 …

Mutation profile of SARS-CoV-2 spike protein and identification of potential multiple epitopes within spike protein for vaccine development against SARS-CoV-2

D Paul, N Pyne, S Paul - Virusdisease, 2021 - Springer
The COVID-19 pandemic worldwide has resulted in over 176 million cases and roughly 3.8
million deaths so far. We could analyze mutation dynamics across the genome from …

The development of SARS-CoV-2 variants: the gene makes the disease

R Perez-Gomez - Journal of developmental biology, 2021 - mdpi.com
A novel coronavirus (SARS-CoV-2) emerged towards the end of 2019 that caused a severe
respiratory disease in humans called COVID-19. It led to a pandemic with a high rate of …

Evolutionary analysis of SARS‐CoV‐2 spike protein for its different clades

MJ Pereson, DM Flichman, AP Martínez… - Journal of Medical …, 2021 - Wiley Online Library
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has
become the main target for antiviral and vaccine development. Despite its relevance, e …

[HTML][HTML] Phylogenetic relationship of SARS-CoV-2 sequences from Amazonas with emerging Brazilian variants harboring mutations E484K and N501Y in the Spike …

F Naveca, V Nascimento, V Souza, A Corado… - Virological …, 2021 - virological.org
Here we report a preliminary genomic analysis of SARS-CoV-2 B. 1.1. 28 lineage circulating
in the Brazilian Amazon region and their evolutionary relationship with emerging and …

[HTML][HTML] SARS-CoV-2 variants–evolution, spike protein, and vaccines

KWK Chen, DTN Huang, LM Huang - biomedical journal, 2022 - Elsevier
Abstracts Despite the rising natural and vaccines mediated immunity, several countries have
experienced a resurgence of the Coronavirus disease of 2019 (COVID-19) due to the …

A potential SARS-CoV-2 variant of interest (VOI) harboring mutation E484K in the Spike protein was identified within lineage B. 1.1. 33 circulating in Brazil

PC Resende, T Gräf, ACD Paixão, L Appolinario… - Viruses, 2021 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was
dominated by two lineages designated as B. 1.1. 28 and B. 1.1. 33. The two SARS-CoV-2 …

Mutations and evolution of the SARS-CoV-2 spike protein

N Magazine, T Zhang, Y Wu, MC McGee, G Veggiani… - Viruses, 2022 - mdpi.com
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the
viral infection that leads to various levels of COVID-19 severities. Positive evolutionary …