Generation of cytotoxic T cells and dysfunctional CD8 T cells in severe COVID-19 patients

SC Gozzi-Silva, LM Oliveira, RW Alberca, NZ Pereira… - Cells, 2022 - mdpi.com
COVID-19, the infectious disease caused by SARS-CoV-2, has spread on a pandemic scale.
The viral infection can evolve asymptomatically or can generate severe symptoms …

Immunosuppression as a hallmark of critical COVID-19: prospective study

E Kalicińska, D Szymczak, A Zińczuk, B Adamik… - Cells, 2021 - mdpi.com
The dysregulation of both the innate and adaptive responses to SARS-CoV-2 have an
impact on the course of COVID-19, and play a role in the clinical outcome of the disease …

Immunological and inflammatory profiles in mild and severe cases of COVID-19

JW Song, C Zhang, X Fan, FP Meng, Z Xu, P Xia… - Nature …, 2020 - nature.com
Abstract COVID-19 is associated with 5.1% mortality. Although the virological,
epidemiological, clinical, and management outcome features of COVID-19 patients have …

T cell activation, highly armed cytotoxic cells and a shift in monocytes CD300 receptors expression is characteristic of patients with severe COVID-19

O Zenarruzabeitia, G Astarloa-Pando, I Terren… - Frontiers in …, 2021 - frontiersin.org
COVID-19 manifests with a wide diversity of clinical phenotypes characterized by
dysfunctional and exaggerated host immune responses. Many results have been described …

Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients

J Westmeier, K Paniskaki, Z Karaköse, T Werner… - MBio, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell
response that most likely contributes to virus control in COVID-19 patients but may also …

A possible role of immunopathogenesis in COVID-19 progression

M Anft, K Paniskaki, A Blazquez-Navarro… - 2020 - pesquisa.bvsalud.org
BackgroundThe role of cellular immunity in pathogenesis of COVID-19 is unclear and
conflicting data points to insufficient or pathogenic immunity as drivers of COVID-19 …

Lymphocyte subset alteration and monocyte CD4 expression reduction in patients with severe COVID-19

S Kazancioglu, FM Yilmaz, A Bastug, A Sakallı… - Viral …, 2021 - liebertpub.com
The spectrum of coronavirus disease 2019 (COVID-19) severity, related to cellular immune
functions, has not been fully clarified yet. Therefore, this study aimed to investigate the …

Characteristics of lymphocyte subset alterations in COVID-19 patients with different levels of disease severity

W Dai, A Zhong, Q Qiao, J Wu, W Li, Q Wu, H Zhou… - Virology journal, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is a respiratory disorder
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which had …

Reduction and exhausted features of T lymphocytes under serological changes, and prognostic factors in COVID-19 progression

A Mahmoodpoor, M Hosseini, S Soltani-Zangbar… - Molecular …, 2021 - Elsevier
Abstract Aims Coronavirus disease 2019 (COVID-19) is a novel viral infection threatening
worldwide health as currently there exists no effective treatment strategy and vaccination …

Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19)

B Diao, C Wang, Y Tan, X Chen, Y Liu, L Ning… - Frontiers in …, 2020 - frontiersin.org
Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health …