Influenza hemagglutinin structures and antibody recognition

NC Wu, IA Wilson - Cold Spring Harbor …, 2020 - perspectivesinmedicine.cshlp.org
Hemagglutinin (HA) is most abundant glycoprotein on the influenza virus surface. Influenza
HA promotes viral entry by engaging the receptor and mediating virus–host membrane …

Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies

PS Lee, IA Wilson - Influenza Pathogenesis and Control-Volume II, 2014 - Springer
Influenza hemagglutinin (HA) is the major surface glycoprotein on influenza viruses and
mediates viral attachment and subsequent fusion with host cells. The HA is the major target …

A perspective on the structural and functional constraints for immune evasion: insights from influenza virus

NC Wu, IA Wilson - Journal of molecular biology, 2017 - Elsevier
Influenza virus evolves rapidly to constantly escape from natural immunity. Most humoral
immune responses to influenza virus target the hemagglutinin (HA) glycoprotein, which is …

Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection

VVA Mallajosyula, M Citron, F Ferrara… - Proceedings of the …, 2014 - National Acad Sciences
Influenza hemagglutinin (HA) is the primary target of the humoral response during
infection/vaccination. Current influenza vaccines typically fail to elicit/boost broadly …

A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface

S Bangaru, S Lang, M Schotsaert, HA Vanderven… - Cell, 2019 - cell.com
Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that
recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts …

A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin

R Xu, JC Krause, R McBride, JC Paulson… - Nature structural & …, 2013 - nature.com
Influenza virus hemagglutinin (HA) mediates receptor binding and viral entry during
influenza infection. The development of receptor analogs as viral-entry blockers has not …

Structural insights into the design of novel anti-influenza therapies

NC Wu, IA Wilson - Nature structural & molecular biology, 2018 - nature.com
A limited arsenal of therapies is currently available to tackle the emergence of a future
influenza pandemic or even to deal effectively with the continual outbreaks of seasonal …

Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody

DD Raymond, G Bajic, J Ferdman… - Proceedings of the …, 2018 - National Acad Sciences
Circulating influenza viruses evade neutralization in their human hosts by acquiring escape
mutations at epitopes of prevalent antibodies. A goal for next-generation influenza vaccines …

Mechanisms of hemagglutinin targeted influenza virus neutralization

B Brandenburg, W Koudstaal, J Goudsmit, V Klaren… - PloS one, 2013 - journals.plos.org
Human monoclonal antibodies have been identified which neutralize broad spectra of
influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies …

Structural biology of influenza hemagglutinin: An amaranthine adventure

NC Wu, IA Wilson - Viruses, 2020 - mdpi.com
Hemagglutinin (HA) glycoprotein is an important focus of influenza research due to its role in
antigenic drift and shift, as well as its receptor binding and membrane fusion functions …