[HTML][HTML] Novel model of tendon regeneration reveals distinct cell mechanisms underlying regenerative and fibrotic tendon healing
To date, the cell and molecular mechanisms regulating tendon healing are poorly
understood. Here, we establish a novel model of tendon regeneration using neonatal mice …
understood. Here, we establish a novel model of tendon regeneration using neonatal mice …
Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration
Tendon injuries are common with poor healing potential. The paucity of therapies for tendon
injuries is due to our limited understanding of the cells and molecular pathways that drive …
injuries is due to our limited understanding of the cells and molecular pathways that drive …
Tendon tissue engineering: An overview of biologics to promote tendon healing and repair
V Citro, M Clerici, AR Boccaccini… - Journal of tissue …, 2023 - journals.sagepub.com
Tendons are dense connective tissues with a hierarchical polarized structure that respond to
and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion …
and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion …
Stepwise differentiation of mesenchymal stem cells augments tendon-like tissue formation and defect repair in vivo
Tendon injuries are common and present a clinical challenge, as they often respond poorly
to treatment and result in long-term functional impairment. Inferior tendon healing responses …
to treatment and result in long-term functional impairment. Inferior tendon healing responses …
Single-cell analysis reveals a nestin+ tendon stem/progenitor cell population with strong tenogenic potentiality
The repair of injured tendons remains a formidable clinical challenge because of our limited
understanding of tendon stem cells and the regulation of tenogenesis. With single-cell …
understanding of tendon stem cells and the regulation of tenogenesis. With single-cell …
Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function
JE Ackerman, KT Best, SN Muscat, EM Pritchett… - Cell reports, 2022 - cell.com
Tendon injuries heal via a scar-mediated response, and there are no biological approaches
to promote more regenerative healing. Mouse flexor tendons heal through the formation of …
to promote more regenerative healing. Mouse flexor tendons heal through the formation of …
Fetal and adult fibroblasts display intrinsic differences in tendon tissue engineering and regeneration
Injured adult tendons do not exhibit optimal healing through a regenerative process,
whereas fetal tendons can heal in a regenerative fashion without scar formation. Hence, we …
whereas fetal tendons can heal in a regenerative fashion without scar formation. Hence, we …
Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis
KT Best, A Korcari, KE Mora, AEC Nichols, SN Muscat… - Elife, 2021 - elifesciences.org
Despite the requirement for Scleraxis-lineage (ScxLin) cells during tendon development, the
function of ScxLin cells during adult tendon repair, post-natal growth, and adult homeostasis …
function of ScxLin cells during adult tendon repair, post-natal growth, and adult homeostasis …
Tgfβ signaling is critical for maintenance of the tendon cell fate
Studies of cell fate focus on specification, but little is known about maintenance of the
differentiated state. In this study, we find that the mouse tendon cell fate requires continuous …
differentiated state. In this study, we find that the mouse tendon cell fate requires continuous …
Molecular regulation of tendon cell fate during development
Although there have been several advances identifying novel mediators of tendon induction,
differentiation, and patterning, much of the basic landscape of tendon biology from …
differentiation, and patterning, much of the basic landscape of tendon biology from …