Many factors have been demonstrated as having an influencing effect on the osteogenic
activity of the peptide‐modified bone repair materials. However, most of studies only focus …

It has been well recognized that the modification of biomaterials with appropriate bioactive
peptides could further enhance their functions. Especially, it has been shown that peptide …

Background Bone tissue engineering and the research surrounding peptides has expanded
significantly over the last few decades. Several peptides have been shown to support and …

The inclusion of biofunctional molecules with synthetic bone graft substitutes has the
potential to enhance tissue regeneration during treatment of traumatic bone injuries. The …

Bioactive biomaterials are desirable as tissue engineering scaffolds by virtue of their
capability to mimic the natural environment of the extracellular matrix. Bioactive biomaterials …

Peptides are attractive as novel therapeutic reagents, since they are flexible in adopting and
mimicking the local structural features of proteins. Versatile capabilities to perform organic …

Since the dawn of human civilisation, biomaterials used for bone tissue engineering have
evolved dramatically. More than 5,000 years ago, the ancient Egyptians used carved shells …

A 15‐mer synthetic peptide, designated P1, was derived from the bone morphogenetic
protein (BMP) receptor I and BMP receptor II binding domains of BMP‐2 for the purpose of …

A critical‐size bone defect cannot repair itself. These defects are presently filled by bone
grafts or with biomaterials that mimic bone properties. The activity of bone cells is modulated …

Covalent binding between bioactive substances and materials in different ways can
significantly improve the bone inductivity and biological activity of bone repair materials …