Organelles are critical structures in mediating the assembly and activation of
inflammasomes in mammalian cells, resulting in inflammation and cell death. Assembly of …

Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …

Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …

Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …

The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the
activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates …

Highlights•The NLRP3, NLRC4, and pyrin inflammasomes are regulated by post-
translational modifications.•The Dhx9-NLRP9b inflammasome recognizing viral dsRNA was …

Inflammasomes are cytosolic multiprotein platforms assembled in response to invading
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …

The inflammasome is a macromolecular protein complex that mediates proteolytic cleavage
of pro-IL-1β and-IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide …

Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-
like receptor (NLR) and PYHIN protein families in response to pathogen-associated …