The X‐linked inherited neuromuscular disorder Duchenne muscular dystrophy is
characterised by primary abnormalities in the membrane cytoskeletal component dystrophin …

Duchenne muscular dystrophy (DMD) leads to disability and death in young men. This
disease is caused by mutations in the DMD gene encoding diverse isoforms of dystrophin …

Introduction: Progressive skeletal muscle wasting is the manifesting symptom of Duchenne
muscular dystrophy, an X-linked inherited disorder triggered by primary abnormalities in the …

Duchenne muscular dystrophy is a highly progressive muscle wasting disorder due to
primary abnormalities in one of the largest genes in the human genome, the DMD gene …

The largest human gene is represented by the X-chromosomal dystrophin gene of 2.4
million bases, which encodes for the membrane cytoskeletal protein dystrophin. The …

In skeletal muscle, the dystrophin-glycoprotein complex forms a membrane-associated
assembly of relatively low abundance, making its detailed proteomic characterization in …

The full-length dystrophin protein isoform of 427 kDa (Dp427), the absence of which
represents the principal abnormality in X-linked muscular dystrophy, is difficult to identify and …

Supramolecular membrane complexes of low abundance are difficult to study by routine
bioanalytical techniques. The plasmalemmal complex consisting of sarcoglycans …

Progressive x-linked muscular dystrophy represents the most commonly inherited
neuromuscular disorder in humans. Although the disintegration of the dystrophin-associated …

Duchenne muscular dystrophy is an inherited disorder of early childhood that affects
multiple systems in the body. Besides late-onset cardio-respiratory syndrome and various …