[HTML][HTML] Transcriptome-wide association studies: recent advances in methods, applications and available databases
Genome-wide association study has identified fruitful variants impacting heritable traits.
Nevertheless, identifying critical genes underlying those significant variants has been a …
Nevertheless, identifying critical genes underlying those significant variants has been a …
TWAS Atlas: a curated knowledgebase of transcriptome-wide association studies
M Lu, Y Zhang, F Yang, J Mai, Q Gao, X Xu… - Nucleic acids …, 2023 - academic.oup.com
Transcriptome-wide association studies (TWASs), as a practical and prevalent approach for
detecting the associations between genetically regulated genes and traits, are now leading …
detecting the associations between genetically regulated genes and traits, are now leading …
twas_sim, a Python-based tool for simulation and power analysis of transcriptome-wide association analysis
Genome-wide association studies (GWASs) have identified numerous genetic variants
associated with complex disease risk; however, most of these associations are non-coding …
associated with complex disease risk; however, most of these associations are non-coding …
Transcriptome‐wide association studies: A view from Mendelian randomization
Background Genome‐wide association studies (GWASs) have identified thousands of
genetic variants that are associated with many complex traits. However, their biological …
genetic variants that are associated with many complex traits. However, their biological …
[PDF][PDF] METRO: Multi-ancestry transcriptome-wide association studies for powerful gene-trait association detection
Integrative analysis of genome-wide association studies (GWASs) and gene expression
studies in the form of a transcriptome-wide association study (TWAS) has the potential to …
studies in the form of a transcriptome-wide association study (TWAS) has the potential to …
Aggregating multiple expression prediction models improves the power of transcriptome-wide association studies
Transcriptome-wide association study (TWAS) is an important integrative method for
identifying genes that are causally associated with phenotypes. A key step of TWAS involves …
identifying genes that are causally associated with phenotypes. A key step of TWAS involves …
Disentangling genetic feature selection and aggregation in transcriptome-wide association studies
The success of transcriptome-wide association studies (TWAS) has led to substantial
research toward improving the predictive accuracy of its core component of genetically …
research toward improving the predictive accuracy of its core component of genetically …
webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study
The development of transcriptome-wide association studies (TWAS) has enabled
researchers to better identify and interpret causal genes in many diseases. However, there …
researchers to better identify and interpret causal genes in many diseases. However, there …
[HTML][HTML] Multi-context genetic modeling of transcriptional regulation resolves novel disease loci
A majority of the variants identified in genome-wide association studies fall in non-coding
regions of the genome, indicating their mechanism of impact is mediated via gene …
regions of the genome, indicating their mechanism of impact is mediated via gene …
How powerful are summary-based methods for identifying expression-trait associations under different genetic architectures?
Y Veturi, MD Ritchie - … 2018: Proceedings of the Pacific Symposium, 2018 - World Scientific
Transcriptome-wide association studies (TWAS) have recently been employed as an
approach that can draw upon the advantages of genome-wide association studies (GWAS) …
approach that can draw upon the advantages of genome-wide association studies (GWAS) …