Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis

CT Baldari, A Onnis, E Andreano, G Del Giudice… - Trends in …, 2023 - cell.com
The COVID-19 pandemic, caused by SARS-CoV-2, has caused an estimated 5 billion
infections and 20 million deaths by respiratory failure. In addition to the respiratory disease …

ACE2 in the era of SARS-CoV-2: controversies and novel perspectives

F Saponaro, G Rutigliano, S Sestito… - Frontiers in Molecular …, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …

Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19

G Li, X He, L Zhang, Q Ran, J Wang, A Xiong… - Journal of …, 2020 - Elsevier
It has been reported that SARS-CoV-2 may use ACE2 as a receptor to gain entry into human
cells, in a way similar to that of SARS-CoV. Analyzing the distribution and expression level of …

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

LI Labzin, KY Chew, K Eschke, X Wang, T Esposito… - Science …, 2023 - science.org
Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease
caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on …

Mechanistic understanding of innate and adaptive immune responses in SARS-CoV-2 infection

MY Balkhi - Molecular Immunology, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have
triggered global pandemic that continue to impact adversely human health. New …

Regulated Intramembrane proteolysis of ACE2: a potential mechanism contributing to COVID-19 pathogenesis?

SM Gonzalez, AB Siddik, RC Su - Frontiers in Immunology, 2021 - frontiersin.org
Since being identified as a key receptor for SARS-CoV-2, Angiotensin converting enzyme 2
(ACE2) has been studied as one of the potential targets for the development of preventative …

SARS-CoV-2 down-regulates ACE2 through lysosomal degradation

Y Lu, Q Zhu, DM Fox, C Gao, SA Stanley… - Molecular Biology of …, 2022 - Am Soc Cell Biol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes its Spike (S)
glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular …

High expression of angiotensin-converting enzyme-2 (ACE2) on tissue macrophages that may be targeted by virus SARS-CoV-2 in COVID-19 patients

X Song, W Hu, H Yu, L Zhao, Y Zhao, Y Zhao - bioRxiv, 2020 - biorxiv.org
Abstract Angiotensin-converting enzyme-2 (ACE2) has been recognized as the binding
receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that infects …

[HTML][HTML] SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

A Onnis, E Andreano, C Cassioli, F Finetti… - Journal of Experimental …, 2022 - rupress.org
CTL-mediated killing of virally infected or malignant cells is orchestrated at the immune
synapse (IS). We hypothesized that SARS-CoV-2 may target lytic IS assembly to escape …

ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection

M Engler, D Albers, P Von Maltitz, R Groß… - Life science …, 2023 - life-science-alliance.org
SARS-CoV-2 triggered the most severe pandemic of recent times. To enter into a host cell,
SARS-CoV-2 binds to the angiotensin-converting enzyme 2 (ACE2). However, subsequent …