Abstract Purpose of Review Anaphylaxis is a severe, life-threatening, systemic allergic
reaction that should be recognized and treated promptly. Intramuscular (IM) epinephrine is …

Abstract Purpose of Review The current standard of first-line emergency treatment of
anaphylaxis is intramuscular (IM) epinephrine, mostly administered through epinephrine …

Some anaphylactic reactions are so severe that treatment is unsuccessful despite rapid
recognition and treatment. Improving the evidence base for the various treatment modalities …

Epinephrine is life-saving and the only first-line medication in the management of
anaphylaxis. At therapeutic doses, it acts rapidly to reverse nearly all symptoms of …

Background Recent acute anaphylaxis guideline updates have identified remaining unmet
needs based on currently available therapeutic options as a critical focus. Objective We …

Epinephrine is the medication of choice in the first-aid treatment of anaphylaxis in the
community. For ethical reasons, it is not possible to conduct randomized, placebo-controlled …

Background In anaphylaxis, the dosing of injectable epinephrine in medical settings has
been arbitrarily recommended to be 0.01 mg/kg of body weight. For ethical reasons, there …

Anaphylaxis is defined as a severe life-threatening, generalized or systemic hypersensitivity
reaction. Yet, anaphylaxis is often difficult to diagnose, leading to a delay in applying …

Anaphylaxis is an acute and potentially lethal multisystem allergic reaction. Most consensus
guidelines for the past 30 years have held that epinephrine is the drug of choice and the first …

International guidelines stipulate that intramuscular (IM) epinephrine (adrenaline) is the first-
line treatment for anaphylaxis, with an established good safety profile. The availability of …