Upon fertilization, drastic chromatin reorganization occurs during preimplantation
development. However, the global chromatin landscape and its molecular dynamics in this …

In mammals, extensive chromatin reorganization is essential for reprogramming terminally
committed gametes to a totipotent state during preimplantation development. However, the …

Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

DNA methylation, chromatin states and their interrelationships represent critical epigenetic
information, but these are largely unknown in human early embryos. Here, we apply single …

Paternal and maternal epigenomes undergo marked changes after fertilization. Recent
epigenomic studies have revealed the unusual chromatin landscapes that are present in …

The dynamics of the chromatin regulatory landscape during human early embryogenesis
remains unknown. Using DNase I hypersensitive site (DHS) sequencing, we report that the …

Human pre-implantation embryonic development involves extensive changes in chromatin
structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables …

Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …

Stability of the epigenetic landscape underpins maintenance of the cell-type-specific
transcriptional profile. As one of the main repressive epigenetic systems, DNA methylation …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …