Mesenchymal stem/stromal cells and their paracrine activity—immunomodulation mechanisms and how to influence the therapeutic potential

R Alvites, M Branquinho, AC Sousa, B Lopes, P Sousa… - Pharmaceutics, 2022 - mdpi.com
With high clinical interest to be applied in regenerative medicine, Mesenchymal
Stem/Stromal Cells have been widely studied due to their multipotency, wide distribution …

Therapeutic mesenchymal stem/stromal cells: value, challenges and optimization

M Najar, R Melki, F Khalife, L Lagneaux… - Frontiers in cell and …, 2022 - frontiersin.org
Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular
environments suitable for tissue repair and regeneration. Among several candidates …

Role of mesenchymal stromal cells as therapeutic agents: potential mechanisms of action and implications in their clinical use

GJ Jimenez-Puerta, JA Marchal, E López-Ruiz… - Journal of clinical …, 2020 - mdpi.com
Due to the great therapeutic interest that involves the translation of mesenchymal stromal
cells (MSCs) into clinical practice, they have been widely studied as innovative drugs, in …

Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential

N Song, M Scholtemeijer, K Shah - Trends in pharmacological sciences, 2020 - cell.com
Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most
promising means of allogeneic cell therapy. MSCs have inherent immunomodulatory …

Mesenchymal stromal cells as multifunctional cellular therapeutics–a potential role for extracellular vesicles

J Stephen, EL Bravo, D Colligan, AR Fraser… - … and Apheresis Science, 2016 - Elsevier
Mesenchymal stromal cells (MSCs), multipotent cells present in tissues throughout the body,
can reconstitute adipogenic, osteogenic and chondrogenic tissues, but are also of great …

The immunoregulatory activity of mesenchymal stem cells:'state of art'and 'future avenues'

A Fierabracci, AD Fattore… - Current medicinal …, 2016 - ingentaconnect.com
Mesenchymal stem cells are spindle-like plastic adherent multipotent cells that can
differentiate into multiple specialized cell types including osteoblasts, chondrocytes and …

TNF-α and IFN-γ participate in improving the immunoregulatory capacity of mesenchymal stem/stromal cells: Importance of cell–cell contact and extracellular vesicles

L López-García, ME Castro-Manrreza - International journal of molecular …, 2021 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) have an immunoregulatory capacity and have
been used in different clinical protocols requiring control of the immune response. However …

Sources and therapeutic strategies of mesenchymal stem cells in regenerative medicine

M Kamal, D Kassem, KH Haider - Handbook of stem cell therapy, 2022 - Springer
During the past decade, mesenchymal stem cells (MSCs) have made their mark as a
potential weapon in regenerative medicine. Since their first isolation by Friedenstein in the …

Mesenchymal stromal cell-based therapy: new perspectives and challenges

M Najar, F Bouhtit, R Melki, H Afif, A Hamal… - Journal of clinical …, 2019 - mdpi.com
Stem cells have been the focus of intense research opening up new possibilities for the
treatment of various diseases. Mesenchymal stromal cells (MSCs) are multipotent cells with …