The importance of nitriles as a key class of chemicals with applications across the sciences
is widely appreciated. The natural world is an underappreciated source of chemically …

Naturally occurring nitriles† comprise a small and surprisingly diverse set of secondary
metabolites. The structures vary from simple, long-chain alkanenitriles to architecturally …

Natural Products Containing a Nitrogen–Nitrogen Bond | Journal of Natural Products ACS ACS
Publications C&EN CAS Find my institution Log In Journal of Natural Products ACS …

This review highlights the medicinal and synthetic chemistry relevance of replacing an
aromatic chloride motif with an aromatic nitrile. We explore the desirable features that this …

The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable
source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by …

Over 30 nitrile-containing pharmaceuticals are prescribed for a diverse variety of medicinal
indications with more than 20 additional nitrile-containing leads in clinical development …

Conspectus Because of the importance of nitrogen-containing compounds in chemistry and
biology, organic chemists have long focused on the development of novel methodologies for …

Covering: up to the end of 2010 Naturally-occurring nitro compounds display great structural
diversity, and a wide range of biological activities. This review summarizes current …

This chapter reviews a selection of the fascinating structures of nitrogen-containing natural
products described during the 25 years to 2015. The structures cited were all structurally …

The nitrile group is an important functional group widely found in both pharmaceutical
agents and natural products. More than 30 nitrile-containing pharmaceuticals have been …