In animals, the sequences for controlling gene expression do not concentrate just at the
transcription start site of genes, but are frequently thousands to millions of base pairs distal …

Eukaryotic genomes are organized in 3D in a multiscale manner, and different mechanisms
acting at each of these scales can contribute to transcriptional regulation. However, the large …

Animal development depends on not only the linear genome sequence that embeds millions
of cis-regulatory elements, but also the three-dimensional (3D) chromatin architecture that …

The spatial organization of the genome is essential for the precise control of gene
expression. Recent advances in sequencing and imaging technologies allow us to explore …

Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …

The relationships among in vivo chromatin structures, chromosome organization and
genome function must be understood in order to reveal the hidden regulatory information in …

The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

The relation between alterations in chromatin structure and changes in gene expression
during cell differentiation has served as a paradigm to understand the link between genome …

The regulation of gene expression is mediated by interactions between chromatin and
protein complexes. The importance of where and when these interactions take place in the …

Recent progresses of genome-wide chromatin conformation capture techniques have
shown that the genome is segmented into hierarchically organized spatial compartments …