Abstract Cardiometabolic disorders are chief causes of morbidity and mortality, with chronic
inflammation playing a crucial role in their pathogenesis. The release of differentiated …

Trained immunity, also known as innate immune memory, is a persistent hyper-responsive
functional state of innate immune cells. Accumulating evidence implicates trained immunity …

Until recently, immunologic memory was considered an exclusive characteristic of adaptive
immunity. However, recent advances suggest that the innate arm of the immune system can …

Ageing and inflammation strongly drive the risk of cardiovascular disease. Work over the
past decade has uncovered a common condition characterized by the positive selection of …

It is now well understood that the bone marrow (BM) compartment can sense systemic
inflammatory signals and adapt through increased proliferation and lineage skewing. These …

A large number of cardiovascular events are not prevented by current therapeutic regimens.
In search for additional, innovative strategies, immune cells have been recognized as key …

Low-grade systemic inflammation is a key pathophysiological component of atherosclerotic
cardiovascular disease (CVD), and long-term activation of myeloid cells is thought to be …

Abstract Purpose of Review Clonal hematopoiesis (CH) is a prevalent condition that results
from the acquisition of somatic mutations in hematopoietic stem cells. When these mutations …

Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune
responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid …

Atherosclerosis is the major cause of cardiovascular disease (CVD). Monocyte-derived
macrophages are the most abundant immune cells in atherosclerotic plaques. In patients …