Gene–environment interaction analysis of serotonin system markers with adolescent depression

TC Eley, K Sugden, A Corsico, AM Gregory… - Molecular …, 2004 - nature.com
We report analyses from a study of gene–environment interaction in adolescent depression.
The sample was selected from 1990 adolescents aged 10–20 years: those with depression …

Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high …

M Laucht, J Treutlein, D Blomeyer… - International Journal …, 2009 - academic.oup.com
Previous research examining gene–environment interaction (G× E) with regard to
vulnerability to depression and anxiety has yielded conflicting results. The present study was …

Gene× environment interactions at the serotonin transporter locus

MR Munafò, C Durrant, G Lewis, J Flint - Biological psychiatry, 2009 - Elsevier
BACKGROUND: Although it is universally accepted that human disease and behavior
depend upon both environmental and genetic variation, a view supported by family and twin …

The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update

R Uher, P McGuffin - Molecular psychiatry, 2010 - nature.com
An updated review of 34 human observational studies indicates that the length
polymorphism of the serotonin transporter gene moderates the effect of environmental …

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis

R Uher, P McGuffin - Molecular psychiatry, 2008 - nature.com
Gene–environmental interaction (G× E) between a common functional polymorphism in the
promoter region of the serotonin transporter gene (5-HTT) and environmental adversity on …

Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles

M Wankerl, R Miller, C Kirschbaum, J Hennig… - Translational …, 2014 - nature.com
The serotonin transporter (SERT) gene-linked polymorphic region (5-HTTLPR) has been
implicated in moderating the link between life stress and depression. However, respective …

Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology

SE Taylor, BM Way, WT Welch, CJ Hilmert… - Biological …, 2006 - Elsevier
BACKGROUND: Mixed evidence has suggested that homozygous carriers of the short allele
(s/s) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may be at …

Life events, first depression onset and the serotonin transporter gene

K Wilhelm, PB Mitchell, H Niven, A Finch… - The British Journal of …, 2006 - cambridge.org
BackgroundA relationship between the serotonin transporter gene, adverse events and
onset of major depression has been reported. AimsTo replicate a gene× environment …

No interaction between the serotonin transporter polymorphism (5‐HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression …

P Chipman, AF Jorm, M Prior, A Sanson… - American Journal of …, 2007 - Wiley Online Library
In this study we investigated interactions between the 5‐HTTLPR genotype and
environmental risk factors (G× E) on symptoms of depression in two large Australian …

The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: a meta-analysis

R Miller, M Wankerl, T Stalder, C Kirschbaum… - Molecular …, 2013 - nature.com
Recent meta-analyses have stimulated an active debate on whether the serotonin
transporter gene-linked polymorphic region (5-HTTLPR) is associated with an elevated …