[HTML][HTML] Branched-chain amino acids and insulin resistance, from protein supply to diet-induced obesity

JP De Bandt, X Coumoul, R Barouki - Nutrients, 2022 - mdpi.com
For more than a decade, there has been a wide debate about the branched-chain amino
acids (BCAA) leucine, valine, and isoleucine, with, on the one hand, the supporters of their …

Insulin resistance and the metabolism of branched-chain amino acids

J Lu, G Xie, W Jia, W Jia - Frontiers of medicine, 2013 - Springer
Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently
causes serious health problems with an increased risk of several common metabolic …

Insulin resistance and the metabolism of branched-chain amino acids in humans

MM Adeva, J Calviño, G Souto, C Donapetry - Amino acids, 2012 - Springer
Peripheral resistance to insulin action is the major mechanism causing the metabolic
syndrome and eventually type 2 diabetes mellitus. The metabolic derangement associated …

Branched chain amino acids in metabolic disease

Z Arany, M Neinast - Current Diabetes Reports, 2018 - Springer
Abstract Purpose of Review Elevations in circulating branched chain amino acids (BCAAs)
have gained attention as potential contributors to the development of insulin resistance and …

Branched chain amino acids—friend or foe in the control of energy substrate turnover and insulin sensitivity?

E Supruniuk, E Żebrowska… - Critical Reviews in Food …, 2023 - Taylor & Francis
Branched chain amino acids (BCAA) and their derivatives are bioactive molecules with
pleiotropic functions in the human body. Elevated fasting blood BCAA concentrations are …

[HTML][HTML] Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state

SH Adams - Advances in nutrition, 2011 - Elsevier
Dysregulation of insulin action is most often considered in the context of impaired glucose
homeostasis, with the defining feature of diabetes mellitus being elevated blood glucose …

[HTML][HTML] Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

M Holeček - Nutrition & metabolism, 2018 - Springer
Branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) are essential amino
acids with protein anabolic properties, which have been studied in a number of muscle …

High dietary protein intake, reducing or eliciting insulin resistance?

A Rietman, J Schwarz, D Tomé, FJ Kok… - European journal of …, 2014 - nature.com
Dietary proteins have an insulinotropic effect and thus promote insulin secretion, which
indeed leads to enhanced glucose clearance from the blood. In the long term, however, a …

Diabetes and branched-chain amino acids: What is the link?

Z Bloomgarden - Journal of diabetes, 2018 - europepmc.org
Branched-chain amino acids (BCAA) have increasingly been studied as playing a role in
diabetes, with the PubMed search string" diabetes" AND" branched chain amino acids" …

[HTML][HTML] Leucine supplementation differently modulates branched-chain amino acid catabolism, mitochondrial function and metabolic profiles at the different stage of …

R Liu, H Li, W Fan, Q Jin, T Chao, Y Wu, J Huang… - Nutrients, 2017 - mdpi.com
The available findings concerning the association between branched-chain amino acids
(BCAAs)—particularly leucine—and insulin resistance are conflicting. BCAAs have been …