[HTML][HTML] Cellular senescence in sarcopenia: possible mechanisms and therapeutic potential

Y He, W Xie, H Li, H Jin, Y Zhang, Y Li - Frontiers in Cell and …, 2022 - frontiersin.org
Aging promotes most degenerative pathologies in mammals, which are characterized by
progressive decline of function at molecular, cellular, tissue, and organismal levels and …

[HTML][HTML] Experimental models of sarcopenia: bridging molecular mechanism and therapeutic strategy

S Mankhong, S Kim, S Moon, HB Kwak, DH Park… - Cells, 2020 - mdpi.com
Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength,
and functions in elderly people. It is accompanied by physical frailty, functional disability …

[图书][B] Sarcopenia–age-related muscle wasting and weakness: mechanisms and treatments

GS Lynch - 2010 - books.google.com
Some of the most serious consequences of aging are its effects on skeletal
muscle.'Sarcopenia', the progressive age-related loss of muscle mass and associated …

[HTML][HTML] Age-related dysfunction in proteostasis and cellular quality control in the development of sarcopenia

HG Paez, CR Pitzer, SE Alway - Cells, 2023 - mdpi.com
Sarcopenia is a debilitating skeletal muscle disease that accelerates in the last decades of
life and is characterized by marked deficits in muscle strength, mass, quality, and metabolic …

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy

TW Buford, SD Anton, AR Judge, E Marzetti… - Ageing research …, 2010 - Elsevier
Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health
concern that continues to grow in relevance as the population ages. Certain conditions have …

[HTML][HTML] Molecular mechanisms and therapeutic interventions in sarcopenia

SS Park, ES Kwon, KS Kwon - Osteoporosis and sarcopenia, 2017 - Elsevier
Sarcopenia is the degenerative loss of muscle mass and function with aging. Recently
sarcopenia was recognized as a clinical disease by the International Classification of …

Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness

JG Ryall, JD Schertzer, GS Lynch - Biogerontology, 2008 - Springer
Some of the most serious consequences of ageing are its effects on skeletal muscle. The
term 'sarcopenia'describes the slow but progressive loss of muscle mass with advancing …

Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention

AP Lightfoot, R McCormick, GA Nye… - Current opinion in …, 2014 - Elsevier
Highlights•Age-related loss of muscle mass and function is a major contributor to
frailty.•Muscles show loss of fibres, atrophy, poor regeneration and adaptive responses.• …

[HTML][HTML] One size may not fit all: anti-aging therapies and sarcopenia

TN Burks, RD Cohn - Aging (Albany NY), 2011 - ncbi.nlm.nih.gov
Sarcopenia refers to age-related loss of muscle mass and function. Several age-related
changes occur in skeletal muscle including a decrease in myofiber size and number and a …

[HTML][HTML] Biochemical pathways of sarcopenia and their modulation by physical exercise: a narrative review

MM Ziaaldini, E Marzetti, A Picca, Z Murlasits - Frontiers in medicine, 2017 - frontiersin.org
Aging is a complex process characterized by progressive multisystem derangement
predisposing individuals to increased risk of developing negative health outcomes …