INTRODUCTION Extensive tumor sequencing efforts have transformed the way in which
cancer driver genes are identified. Appropriate statistical modeling is crucial for …

APOBEC mutagenesis, a major driver of cancer evolution, is known for targeting TpC sites in
DNA. Recently, we showed that APOBEC3A (A3A) targets DNA hairpin loops. Here, we …

Elucidation of mutagenic processes shaping cancer genomes is a fundamental problem
whose solution promises insights into new treatment, diagnostic and prevention strategies …

Mutational signatures defined by single base substitution (SBS) patterns in cancer have
elucidated potential mutagenic processes that contribute to malignancy. Two prevalent …

The APOBEC3 family of cytosine deaminases has been implicated in some of the most
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …

Thousands of somatic mutations accrue in most human cancers, and their causes are
largely unknown. We recently showed that the DNA cytidine deaminase APOBEC3B …

Deep sequencing technologies are revealing the complexities of cancer evolution, casting
light on mutational processes fueling tumor adaptation, immune escape, and treatment …

APOBEC3A and APOBEC3B, cytidine deaminases of the APOBEC family, are among the
main factors causing mutations in human cancers. APOBEC deaminates cytosines in single …

Certain mutagens, including the APOBEC3 (A3) cytosine deaminase enzymes, can create
multiple genetic changes in a single event. Activity of A3s results in striking 'mutation …

Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …