Independent effect and joint effect of polygenic liabilities for schizophrenia and bipolar disorder on cognitive aging and education attainment

CS Wu, CL Hsu, MC Lin, MH Su, YF Lin, CY Chen… - medRxiv, 2022 - medrxiv.org
To elucidate the specific and shared genetic background of schizophrenia (SCZ) and bipolar
disorder (BPD) to better understand their nosology, this study explored the independent and …

Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence

OB Smeland, S Bahrami, O Frei, A Shadrin… - Molecular …, 2020 - nature.com
Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with
cognitive impairment, which is considered a major determinant of functional outcome …

Cognitive performances across individuals at high genetic risk for schizophrenia, high genetic risk for bipolar disorder, and low genetic risks: a combined polygenic …

K Ohi, D Nishizawa, S Sugiyama, K Takai… - Psychological …, 2023 - cambridge.org
BackgroundIndividuals with schizophrenia (SCZ) and bipolar disorder (BD) display cognitive
impairments, but the impairments in those with SCZ are more prominent, supported by …

Polygenic risk scores differentiating schizophrenia from bipolar disorder are associated with premorbid intelligence in schizophrenia patients and healthy subjects

K Ohi, D Nishizawa, S Sugiyama, K Takai… - International Journal …, 2021 - academic.oup.com
Background Impairments in intelligence are more severe in patients with schizophrenia
(SCZ) than in patients with bipolar disorder (BD) despite clinical and genetic similarities …

Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect

M Ikeda, A Takahashi, Y Kamatani… - Schizophrenia …, 2019 - academic.oup.com
Genome-wide association studies (GWASs) have identified> 100 susceptibility loci for
schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by …

Genome-Transcriptome-Functional Connectivity-Cognition Link Differentiates Schizophrenia From Bipolar Disorder

J Chen, Z Fu, JR Bustillo… - Schizophrenia …, 2022 - academic.oup.com
Abstract Background and Hypothesis Schizophrenia (SZ) and bipolar disorder (BD) share
genetic risk factors, yet patients display differential levels of cognitive impairment. We …

Investigating the source of increased bipolar and major depressive disorder polygenic risk in multiplex schizophrenia families

M Ahangari, R Kirkpatrick, TH Nguyen, N Gillespie… - medRxiv, 2021 - medrxiv.org
Psychotic and affective disorders often aggregate in the relatives of probands with
schizophrenia (SCZ), and genetic studies show substantial genetic correlation among SCZ …

Genome-wide association studies of schizophrenia and bipolar disorder in a diverse cohort of US Veterans

T Bigdeli, A Fanous, Y Li… - Biological …, 2020 - biologicalpsychiatryjournal.com
Background Schizophrenia (SCZ) and bipolar disorder (BIP) are debilitating
neuropsychiatric illnesses collectively affecting 2% of the world's population. Recognizing …

T104. IS GENETIC BURDEN IN BIPOLAR DISORDER ASSOCIATED WITH COGNITIVE PERFORMANCE? A POLYGENIC RISK SCORE ANALYSIS

G Fico, L Montejo, C Torrent, B Sole, N Roberto… - European …, 2023 - Elsevier
Background Individuals with bipolar disorder (BD) experience cognitive deficits across
various domains, including attention, memory, and executive functions. The use of polygenic …

Polygenic risk of schizophrenia and cognition in a population-based survey of older adults

DT Liebers, M Pirooznia, F Seiffudin… - Schizophrenia …, 2016 - academic.oup.com
Cognitive impairment is a common feature of the major psychotic disorders, with deficits
often present in at risk individuals and unaffected first-degree relatives. Previous studies …