Matrin-3 (MATR3) was initially discovered as a component of the nuclear matrix about thirty
years ago. Since then, accumulating studies have provided evidence that MATR3 not only …

The dysfunction of many RNA-binding proteins (RBPs) that are heavily disordered, including
TDP-43 and FUS, are implicated in amyotrophic lateral sclerosis and frontotemporal …

Abnormalities in nucleic acid processing are associated with the development of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in Matrin …

Mutations in the MATR3 gene encoding the nucleotide binding protein Matrin 3 have
recently been identified as causing a subset of familial amyotrophic lateral sclerosis (fALS) …

Matrin 3 is a nuclear matrix protein that has many roles in RNA processing including splicing
and transport of mRNA. Many missense mutations in the Matrin 3 gene (MATR3) have been …

Simple Summary Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease
affecting the motor neurons in the brain and spinal cord. Mutations in the gene Matr3 have …

Matrin‐3 (MATR3) is an RNA‐binding protein implicated in neurodegenerative and
neurodevelopmental diseases. However, little is known regarding the role of MATR3 in …

RNA-binding protein (RBP) dysfunction is a fundamental hallmark of amyotrophic lateral
sclerosis (ALS) and related neuromuscular disorders. Abnormal neuronal excitability is also …

RNA-binding proteins (RBPs) are essential factors required for the physiological function of
neurons, muscle, and other tissue types. In keeping with this, a growing body of genetic …

RNA-binding protein (RBP) dysfunction is a fundamental hallmark of amyotrophic lateral
sclerosis (ALS) and related neuromuscular disorders. Abnormal neuronal excitability is also …