In the protozoa parasite Giardia lamblia, endocytosis and lysosomal protein trafficking are
vital parasite-specific processes that involve the action of the adaptor complexes AP-1 and …

Giardia lamblia is an early branching protist that possesses peripheral vacuoles (PVs) with
characteristics of lysosome-like organelles, located underneath the plasma membrane. In …

Epsins serve as recruitment platforms for clathrin membrane coat protein components and
induce membrane curvature via their N-terminal homology (ENTH) domain. Unexpectedly …

The parasite Giardia lamblia possesses PVs (peripheral vacuoles) that function as both
endosomes and lysosomes and are implicated in the adaptation, differentiation and survival …

In Giardia, lysosome-like peripheral vacuoles (PVs) need to specifically coordinate their
endosomal and lysosomal functions to be able to successfully perform endocytosis, protein …

The phylum Apicomplexa includes a large group of early branching eukaryotes having
significant medical and economical importance. The molecular machinery responsible for …

Endocytosis, which is important for the internalization of nutrients from the plasma
membrane as well as extracellular fluids, has been extensively described in mammalian …

Giardia, an early diverging eukaryote, is reported to have no Golgi apparatus. Moreover, the
structural basis for its ability to sort key proteins and transport them to the trophozoite plasma …

Epsin N‐terminal homology (ENTH) domains occur in proteins of either the epsin or epsin‐
related (epsinR) form. They principally function in clathrin‐mediated trafficking and …

Giardia is a flagellated protozoan parasite that has to face different microenvironments
during its life cycle in order to survive. All cells exchange materials with the extracellular …