Drug development is a complex, risky, expensive and time-consuming process that requires
the accurate execution of multiple stages, from identification and selection of collections of …

The landscape of small-molecule drug discovery has undergone substantial changes over
the past 20 years, in which the testing of tens to hundreds of compounds in animal models …

Natural products (NPs) are a rich source of structurally novel molecules, and the chemical
space they encompass is far from being fully explored. Over history, NPs have represented a …

The number of approved drugs for the market is decreasing in recent years and calls for
more effective methods to discover a higher number of successful compound candidates …

In this study, we evaluated 3444 Latin American natural products using cheminformatic
tools. We also characterized 196 compounds for the first time from the flora of El Salvador …

Natural products or other drug structures have served as lead structures for the majority of
drugs launched during the past 100 years. The process of using other drug structures as …

Compound databases of natural products have a major impact on drug discovery projects
and other areas of research. The number of databases in the public domain with compounds …

Drug discovery is a process by which novel potential medicines are identified via a series of
critical research activities. It comprises a variety of scientific fields, including pharmacology …

The nature remains as the potential source of organic structures of unparalleled diversity.
Successful drug discovery process is often a function of the diversity of chemotypes …

Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …