Alzheimer's disease (AD) is presently the 6th major cause of mortality across the globe.
However, it is expected to rise rapidly, following cancer and heart disease, as a leading …

Reactive astrocyte proliferation is involved in many central degenerative diseases. The
enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase isoform 3 (PFKFB3), an …

Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a ubiquitous enzyme that
catalyzes the sixth step of glycolysis and thus, serves to break down glucose for energy …

Glucose uptake in the brain decreases because of normal aging but this decline is
accelerated in Alzheimer's disease (AD) patients. In fact, positron emission tomography …

Phosphofructo-2-kinase/fructose-2, 6-bisphosphatase-3 (PFKFB3) is a master regulator of
glycolysis by its ability to synthesize fructose-2, 6-bisphosphate, a potent allosteric activator …

Glycogen synthase kinase 3β (GSK3β) is a key component of pathogenesis in Alzheimer's
disease, and its inhibitors can restore cognitive function as therapeutic interventions in …

Brain consumes nearly 20% supply of energy from glucose metabolism by oxidative
phosphorylation and aerobic glycolysis. Less active state of glycolytic enzymes results in a …

Alzheimer's disease (AD) is an extremely popular neurodegenerative condition associated
with dementia, responsible for around 70% of the cases. There are presently 50 million …

Following inhibition of mitochondrial respiration neurons die rapidly, whereas astrocytes
utilize glycolytically-generated ATP to increase their mitochondrial membrane potential, thus …

Objective Astrocytes actively participate in energy metabolism in the brain, and astrocytic
aerobic glycolysis disorder is associated with the pathology of Alzheimer's disease (AD) …