Zebrafish is an intriguing model organism known for its remarkable cardiac regeneration
capacity. Studying the contracting heart in vivo is essential for gaining insights into structural …

Despite ongoing efforts in cardiovascular research, the acquisition of high-resolution and
high-speed images for the purpose of assessing cardiac contraction remains challenging …

Embryonic cardiac research has greatly benefited from advances in fast in vivo light sheet
fluorescence microscopy (LSFM). Combined with the rapid external development, tractable …

Biomechanical forces intimately contribute to cardiac morphogenesis. However, volumetric
imaging to investigate the cardiac mechanics with high temporal and spatial resolution …

Detailed studies of heart development and function are crucial for our understanding of
cardiac failures and pave the way for better diagnostics and treatment. However, the …

Currently, there is a limited ability to interactively study developmental cardiac mechanics
and physiology. We therefore combined light-sheet fluorescence microscopy (LSFM) with …

Abstract Light Sheet Fluorescence Microscopy (LSFM) enables multi-dimensional and multi-
scale imaging via illuminating specimens with a separate thin sheet of laser. It allows rapid …

Zebrafish (Danio rerio) larvae are emerging as high-throughput, chemical screening assays
for investigating congenital cardiomyopathies. Despite distinct anatomical and genomic …

Organogenesis depends on orchestrated interactions between individual cells and
morphogenetically relevant cues at the tissue level. This is true for the heart, whose function …

Abstract Purpose of Review Real-time 3-dimensional (3-D) imaging of cardiovascular injury
and regeneration remains challenging. We introduced a multi-scale imaging strategy that …